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Earth Abides
by by George R. Stewart (1949)

Classic disaster story in which most of humankind is wiped out by a destructive virus. Isherwood Williams, a survivor living in California, finds a mate and goes about helping to repopulate the earth. He becomes the last vestige of the old civilisation. What Williams ultimately discovers will prove far more astonishing than anything he'd either dreaded or hoped for.

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I Am Legend
by Richard Matheson (1954)

Robert Neville is the last living man on Earth... but he is not alone. Every other man, woman and child on the planet has succumbed to the vampire plague, and they are hungry for Neville's blood. By day he is the hunter, stalking the undead through the ruins of civilisation. By night, he barricades himself in his home and prays for the dawn. Classic horror story with a sprinkling of sci-fi credentials.

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The Andromeda Strain
by Michael Crichton (1969)

Scientists warn the US government that current sterilization procedures applied to returning space probes may be inadequate to guarantee uncontaminated re-entry to the atmosphere. Two years later, seventeen satellites are sent into the outer fringes of space to collect organisms and dust for study. One of them falls to earth and a team of scientists is sent to clean up the mess.

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The Lathe of Heaven
by Ursula K. Le Guin (1971)

In a future world racked by violence and environmental catastrophes, George Orr wakes up one day to discover that his dreams have the ability to alter reality. His psychotherapist seizes on the chance to play God. The overpopulation problem is solved when Orr changes history by dreaming up a plague. Next... what to do about the race question, as he struggles to preserve reality.

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Darwin's Radio
by Greg Bear (1999)

A mass grave of mutated villagers, a mummified Neanderthal family, and a new disease that strikes pregnant women... three seemingly unrelated occurrences Molecular biologist Kaye Lang's theory - that diseases encoded in the DNA of humans can return to life - has become a chilling reality. A "virus-hunter" has tracked down a disease that kills expectant mothers and their offspring.

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Chasm City
by Alastair Reynolds (2001)

Chasm City - a doomed human settlement on an inhospitable planet - has been overrun by a virus known as the Melding Plague, capable of infecting any body, organic or computerised. For operative Tanner Mirabel, it is the landscape of nightmares through which he searches for a low-life postmortal killer. He comes face to face with a centuries-old atrocity that history would rather forget.

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Prey
by Michael Crichton (2002)

In the Nevada desert, an experiment has gone horribly wrong. A cloud of nanoparticles - micro-robots - has escaped from the laboratory. It is self-reproducing, intelligent and learns from experience. For all practical purposes, it is alive. It has been programmed as a predator. It is becoming more deadly with each passing hour. Every attempt to destroy it has failed. And we are the prey.

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Lock In [S1]
by John Scalzi (2014)

A highly contagious virus affects an unlucky one percent of the world's population with the disease 'Lock In'. It leaves victims fully awake and aware, but unable to move or respond to stimulus. A quarter of a century after its appearance, two FBI agents are assigned to a murder case involving an 'integrator', someone who can let the locked in borrow their bodies for a time.